Many have 'disk' in their name, although disks, especially internal ones, are now a thing of the past. Macs simply do not need 'cleaning.' (See for example: ) Some of these programs are notorious for being little more than malware. True experts in macOS maintenance advise against using any of them, because in general they serve little useful purpose and they can easily do more harm than good.
Most of the developers' descriptions boast about what a great job they do, but the truth is, there are no good, comprehensive, head-to-head reviews of these programs by impartial 3rd parties. Many - probably the most accurate and honest - have negative reviews, by users who have been burned by them. Many have what look to be essentially fake 5-star reviews with no useful commentary. There are now 76 (that's SEVENTY-SIX) programs in the list, and it seems like new entries in the 'Mac cleaner' market space pop up every day, metastasizing like a cancer. Before you even *think* of installing any of them, PLEASE read this. As a public service to the MacUpdate community, I've found as many of these 'cleaner' apps on this website as I could and listed them them below. This is not a review per se, it is a discussion of the class of software to which this program belongs.